세포주 정보

PC-12
PC-12
KCLB NO
21721
Name
PC-12
세포주 분양조건
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Origin
adrenal gland
Species
rat male
Receptor
nerve growth factor (NGF)
Tumorigenecity
yes, in New England Deaconess Hospital strain rats
Karyology
40 chromosomes; 38 autosomes plus XY
Cellular morphology
polygonal
Production
catecholamines; dopamine; norepinephrine
Growth Pattern
small clusters, poorly adherent
Histopathology
pheochromocytoma
준비중입니다.
freeze media
RPMI1640, 52.5%; FBS, 40%; DMSO, 7.5%
original medium
RPMI1640, 85%; heat-inactivated horse serum, 10%; heat inactivated fetal bovine serum (FBS), 5%
kclb media
RPMI1640 with L-glutamine (300mg/L), 25mM HEPES and 25mM NaHCO3, 90%; heat inactivated fetal bovine serum (FBS), 10%
note
the PC-12 cell line was derived from a transplantable rat pheochromocytoma; the cells respond reversibly to NGF by induction of the neuronal phenotype; the cells do not synthesize epinephrine; PC-12 adheres poorly to plastic, and tends to grow in small clusters; attachment is improved by using collagen coated flasks.
Proc Nat'l Acad Sci USA, 73:2424-2426, 1976; Science, 229:393-395, 1985; EMBO, 2:643-648, 1983